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The vertebrate immune system is composed of two parts, innate immunity which recognizes the invading microbes using germline-encoded molecules, and adaptive immunity, which depends on recognition molecules generated by somatic mechanisms during the ontogeny of each individual organism ( 1997).

All data available to date indicate that adaptive immunity became established at the early stage of vertebrate evolution around the time of cartilaginous fish emergence.

Thus the genes which encode the pivotal elements of adaptive immunity, such as immunoglobulin ( 1995) have been identified in cartilaginous fish and higher vertebrates.

In contrast, vertebrate innate immunity is believed to have a more ancient origin, and an apparently primitive complement system has been found in lamprey ( et al. However, it was not clear until recently whether the origin of the complement system can be traced back to invertebrate.

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A state appeals court judge ruled Saturday that Southern California Gas Co.

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The Los Angeles Times series “Dirty John” tells the story of a grifter in Orange County who lied to and manipulated his wife.

The number of Americans diagnosed with chlamydia, gonorrhea or syphilis reached a record high in 2016 for the second year in a row, with more than 2 million cases reported and particularly high rates in California, according to federal data released Tuesday.

Los Angeles County health officials warned residents Monday to protect themselves against the mosquitoes that transmit West Nile virus, as the number of people killed by the disease in L.

Julie Shepherd ended up in the hospital earlier this month after her neighbor found her on the floor of her West Covina home, unable to move.

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