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Most squamous cell anal cancers are linked to infection with the human papillomavirus (HPV), the same virus that causes cervical cancer, as well as many other kinds of cancer.

In fact, women with a history of cervical cancer (or pre-cancer) have an increased risk of anal cancer. They are called papillomaviruses because some of them cause papillomas, which are more commonly known as warts.

There are many subtypes of HPV, but the one most likely to cause anal cancer is HPV-16.

Other subtypes of HPV can cause warts in the genital and anal areas, but not cancer.

The 2 types of HPV that cause most cases of anal and genital warts are HPV-6 and HPV-11.

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